High-dimensional characterization of genome-environment fitness landscapes in Klebsiella pneumoniae
Published in medRxiv (preprint), 2026
Recommended citation: Zhou, G., Williams, G., Millner, M. T., AlHirayban, R., Alosaimi, W., Fallatah, O., Hart, A. J., Malaikah, M., Iftikhar, S., et al., & Moradigaravand, D. (2026). High-dimensional characterization of genome-environment fitness landscapes in Klebsiella pneumoniae. medRxiv. https://doi.org/10.64898/2026.05.28.26354339
This study profiled 1,462 clinical K. pneumoniae isolates across 214 environmental and pharmacological stress conditions. Fitness measurements were integrated with whole-genome sequencing, GWAS, and machine-learning models.